Relevant glycoconjugates on the surface of Trypanosoma cruzi
نویسندگان
چکیده
منابع مشابه
Relevant glycoconjugates on the surface of Trypanosoma cruzi.
Although Chagas disease has been discovered 90 years ago, only after 1970 substantial progress has been made in the knowledge of molecular aspects of the host-parasite interaction. The amount of information gathered in the past 30 years was considerable, making it virtually impossible to cover all aspects of the biochemistry and molecular biology of the Trypanosoma cruzi, the etiologic agent of...
متن کاملEffects of some fractions from Achillea biebersteinii and A.millefolium on the epimastigotes of Trypanosoma cruzi
Higher plants are a potential source of new drugs to improve the treatment of Chagase disease, which is affecting 16-18 million people, with more than 100 million exposed to the risk of infection (Ambrozin et al., 2004; Coura & Castro, 2002). Current therapy is unsatisfactory, because the only two drugs available, benznidazole and nifortimox possess severe side effects and their activity is lim...
متن کاملEffects of some fractions from Achillea biebersteinii and A.millefolium on the epimastigotes of Trypanosoma cruzi
Higher plants are a potential source of new drugs to improve the treatment of Chagase disease, which is affecting 16-18 million people, with more than 100 million exposed to the risk of infection (Ambrozin et al., 2004; Coura & Castro, 2002). Current therapy is unsatisfactory, because the only two drugs available, benznidazole and nifortimox possess severe side effects and their activity is lim...
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It was shown in this work that the infectivity of metacyclic forms of Trypanosoma cruzi was affected upon interaction with the monoclonal antibody (10D8), which reacts with a carbohydrate epitope of the 35- and 50-kilodalton (kDa) surface glycoconjugates. The invasion of Vero cells by metacyclic forms of strains Tulahuen and G was inhibited 50 to 67% in the presence of 10D8 (10 micrograms/ml), ...
متن کاملAnti-Trypanosoma cruzi activity of extracts from Argentinean Asteraceae species
The anti-Trypanosoma cruzi activity of extracts from 13 Argentinean Asteraceae species was determined. Dichloromethane and methanol extracts of Acmella bellidioides, Aspilia silphioides, Viguiera tuberosa, Calyptocarpus biaristatus, Hyalis argentea, Helenium radiatum, Gaillardia megapotamica, Verbesina subcordata, Gymnocoronis spilanthoides, Viguiera anchusaefolia, Thelesperma megapotamicum, Ze...
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ژورنال
عنوان ژورنال: Memórias do Instituto Oswaldo Cruz
سال: 1999
ISSN: 0074-0276
DOI: 10.1590/s0074-02761999000700004